EVE - SCIENCE AT A GLANCE

EVE as part of the RXR protein has an important role in many fundamental biological process such as cell reproduction, cellular differentiation, bone development, hematopoesis (formation of blood cellular components) and pattern formation during embryogenesis.
 
DETAILED FUNCTIONS:
TRANSDUCTION OF RETINOIC ACID SIGNALS

  • Morphogenesis
        Morphogenesis is concerned with the shapes of tissues,
        organs and entire organisms and the positions of the various
        specialized cell types.


  • Organogenesis:
        Organogenesis is the process by which the
        ectoderm, endoderm, and mesoderm develop into the
        internal organs of the organism.


  • Cellular growth


  • Cellular differentiation


  • Homeostasis:
        Homeostasis is the property of a living organism to
        regulate its internal environment so as to maintain a
        stable,constant condition.
        ex: control of temperature, regulation of
        blood glucose, as well as the concentration of blood)


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    Amino acid sequence (1 letter code)

    >1LBD:A|PDBID|CHAIN|SEQUENCE

    MGSSHHHHHHSSGLVPRGSHKREAVQEERQRGKDRNENEVESTS
    SANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQ
    LFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILL
    ATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFN
    PDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSI
    GLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT


    AMINO ACIDS:
    GLU* - VAL* - GLU*

    PROTEIN NAME:
    Retinoid X Receptor

    TOTAL NUMBER OF AMINO ACIDS:
    282

    TYPE:
    Nuclear receptor

    STRUCTURE:
    modular architecture

    SOURCE ORGANISM:
    Human

    *(GLU: Glutamic acid) / (VAL: Valin)


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